Laboratory of Dr. Ian Haworth

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USC Pharm.Sciences


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 My laboratory uses computer simulation and gel electrophoresis to study the molecular interactions and reactions between small molecules and DNA. We use these techniques to study the polyamine-DNA interaction, and to investigate mechanisms of DNA alkylation by anti-tumor agents.

We also use simulation approaches to study a number of ligand interactions with proteins. We have active research in the areas of peptide-MHC interactions, in the computer-aided design of TGF-beta Inhibitors.

We are also developing new computational methods to generate DNA molecules in any conformation and to simulate DNA conformational transitions. In this context, we have a particular interest in conformations adopted by trinucleotide repeat DNA sequences.