Last Updated 8/10/04
NOTE: THIS IS THE PUBLIC WEBSITE!!
STUDENTS REGISTERED FOR THE COURSE SHOULD USE THIS LINK TO GET TO THE ACTUAL COURSE WEBSITE.
FALL 2004
Course Information:
INTD 531 is a graduate level, in depth, course in Cell Biology, offered on the Health Sciences Campus. A number of different subject areas of research significance will be covered in this course, however, it is impossible to cover all areas of cell biology in as much depth as we would like in the time we have allotted. Five major areas will be emphasized: 1) Membranes and membrane function, 2) growth, metabolism, and signal transduction, 3) cytoskeleton 4) intracellular trafficking and 5) the cell and its envrironment. Each of these major areas will be organized by a separate faculty member as shown below. The course will use the material in the text as a starting point, and original recent work and advances in the individual areas will be emphasized.
IMPORTANT!
Throughout the course: STUDENTS WILL BE COMMUNICATED WITH BY EMAIL. PLEASE BRING YOUR EMAIL ADDRESS WITH YOU TO THE FIRST CLASS!
Course format:
The course will consist of two, two-hour sessions per week. Class will meet 9-11 AM on Tuesdays and Thursdays in McKibben 256 lecture hall. The lecture schedule and assigned lecturers are listed in the table at the bottom of this page.
THE FIRST DAY OF LECTURE IS AUGUST 24, 2004.
EXAM DATES and LOCATIONS:
EXAM I: SEPTEMBER 16 Location TBA
EXAM II: OCTOBER 26 Location TBA
EXAM III: DECEMBER 10 Location TBA (Note -- this is a FRIDAY)
Anyone who has conflicts with the above third exam date: Contact jgarner@usc.edu for other arrangements.
Text:
The required text is the most recent edition ( Fourth) of Alberts,
Johnson, Lewis, Raff, Roberts and Walter THE MOLECULAR BIOLOGY OF
THE CELL.
Discussion sections:
At the end of each series of lectures in these major areas, there may be a discussion section. At the beginning of each series of lectures, the instructor in charge of the series will describe the format of the discussion section for that particular series of lectures. It may involve a problem solving session or could involve reading a limited set of papers on a particular relevant research topic, and meeting in smaller discussion groups to discuss the implications of those papers. Information covered in the discussion sessions is included as testable material on the exams.
Exams:
There will be three 2-hour exams as indicated on the course schedule, each counting for 1/3 of the grade for the course and each will cover the section of the course immediately preceding the exam (usually 8-10 sessions). The exams will be essay and short answer exams, and examination questions will be written and graded by the faculty giving individual lectures.
SECTION LEADERS :
| SECTION | FACULTY MEMBER | TELEPHONE | |
| Course Oversight | Judy A. Garner, Ph.D.Associate Professor, Cell and Neurobiology | (323) 442-1296 | jgarner@usc.edu |
| Website Oversight | Judy A. Garner, Ph.D.Associate Professor, Cell and Neurobiology | (323) 442-1279 | jgarner@usc.edu |
| Membranes and Membrane Function | Austin Mircheff, Ph.D.,Professor, Physiology and Biophysics | (323) 442-1242 | amirchef@usc.edu |
| Growth Control and Regulation: | Axel Schönthal, Ph.D., Associate Professor, Microbiology | (323) 442-1730 | schontha@usc.edu |
| Cytoskeleton: | Judy A. Garner, Ph.D.,Associate Professor, Cell and Neurobiology | (323) 442-1279 | jgarner@usc.edu |
| Intracellular trafficking: | Curtis Okamoto, Ph.D. Associate Professor, Pharmaceutical Sciences | (323) 442-3939 | cokamoto@usc.edu |
| Cell and Its Environment | Cheng-Ming Chuong, M.D., Ph.D., Professor, Pathology | (323) 442-1296 | chuong@pathfinder.usc.edu |
Lecturers:
Daniel Broek, Ph.D., Associate Professor, Norris Cancer Center, 865-0523, email: broek@usc.edu
Robert Chow, M.D., Ph.D., Associate Professor, Physiology and Biophysics, 2-2901, email rchow@usc.edu
Cheng-Ming Chuong, M.D., Ph.D., Professor, Pathology, 442-1296 email: chuong@pathfinder.usc.edu
Yves Declerck, M.D.., Professor, Pediatrics/Children's Hospital , (323)669-2150 email: declerck@usc.edu
Robert Farley, Ph.D., Professor, Physiology and Biophysics, 442-1240, email: rfarley@usc.edu
Judy Garner, Ph.D. Associate Professor, Cell and Neurobiology, 442-1279 email: jgarner@usc.edu
Sarah Hamm-Alvarez, Ph.D., Associate Professor, Pharmaceutical Sciences, 442-1445 email: shalvar@usc.edu
Wei Li, Associate Professor, Medicine, 323-224-7058, email :wli@usc.edu
Austin Mircheff, Ph.D., Professor, Physiology and Biophysics, 442-1242 email: amirchef@usc.edu
Curtis Okamoto, Ph.D., Associate Professor, Pharmaceutical Sciences, 442-3939 email: cokamoto@usc.edu
Axel Schönthal, Ph.D., Associate Professor, Molecular Microbiology and Immunology, 442-1730 email: schontha@usc.edu
P. Elyse Schauwecker, Ph.D., Associate Professor, Cell and Neurobiology, 442-2116 email: schauwec@usc.edu
Tai-Lan Tuan, Ph.D., Assistant Professor, Pediatrics/Children's Hospital (323) 669-4183, email: tuan@usc.edu
Randall Widelitz, Ph.D., Assistant Professor, Pathology, 442-1158 email: widelitz@pathfinder.usc.edu
(Individual Lecture times and titles of the later sessions will still change:
initial series of lectures is confirmed)
FALL SEMESTER 2004
| DATE | .LECTURER | |
| 8/24 | Structure of cell membranes | Farley |
| 8/26 | Principles of carrier mediated transport, facilitated diffusion, channels and pores. | Farley |
| 8/31 | Active Transport: Primary and Secondary | Farley |
| 9/2 | Electrochemical potential and transport between compartments | Mircheff |
| 9/5 | Nernst equation. Osmotic pressure. Gibbs-Donnan Equilibrium | Mircheff |
| 9/7 | Diffusion. Electrolyte diffusion and development of transmembrane potential. | Mircheff |
| 9/14 | DISCUSSION: Transport and cellular homeostasis. Spatial organization of transport functions in epithelia. | Mircheff/Farley |
| 9/16 |  Membranes and membrane function
|
|
| 9/21 | Microfilament structure, function and specializations. Actin interactions with actin binding proteins. | Garner |
| 9/23 | Microtubule structure and function: Microtubule specializations: Centrioles, cilia, and flagella | Hamm-Alvarez |
| 9/28 | Intermediate filament structure, function and specializations. | Garner |
| 9/30 | Motors | Hamm-Alvarez |
| 10/5 | Discussion Section | Hamm-Alvarez/Garner |
| 10/7 | Apoptosis | Schauwecker |
| 10/12 | Mitochondrial Dysfunction and Cell Death | Schauwecker |
| 10/14 | Kinases and phosphatases | Schönthal |
| 10/19 | TBA | Li |
| 10/21 | Rho GTPases in regulation of the cytoskeleton and gene expression | Broek |
| 10/26 |
EXAM
II: |
|
| 10/28 | Cell Cycle/Growth Control |
Schönthal |
INTRACELLULAR TRAFFICKING: Dr. Okamoto |
||
| 11/2 | Membrane protein synthesis and quality control | Okamoto |
| 11/4 | EXOCYTOSIS 1 | Chow |
| 11/9 | EXOCYTOSIS 2 | Chow |
| 11/11 | Endocytosis | Okamoto |
| 11/16 | Introduction to adhesion molecules, assays and categories. Genetic diseases involving adhesion. | Chuong |
| 11/18 | Cadherin/catenin // Extracellular Matrix | Widelitz |
| 11/23 | Inflammation and wound healing | Tuan |
| 11/30 | Tumor metastasis, angiogenesis. Proteases and their inhibitors. | Declerck |
| 12/2 | Discussion section | Tuan/Staff |
| 12/10 |
EXAM III: |