Lian-Song Chen, M.D.

Personal information:

  • Working Address:    
    Department of Pathology,     Los Angeles County Hospital+USC Medical Center, University of Southern California.
    1200 N State Street, Los Angeles, CA 90033
  • Telephone number:       (323)-226-7148 (Office)       
  • Fax number:        323-226- xxxx       
  • E-mail:        lianchen@hsc.usc.edu.

    Education:

    1981-1986       M.D.        With Honors, Magna Cum Laude (top one percent).      Hunan Medical University, Changsha, Hunan Province, China.

    Clinical activities in United States:

    1998-1999:        Physician Externship.       Women's and Children's Hospital, Los Angeles County Hospital+University of Southern California.        I was seeing patients in pediatric clinic of hematology with Dr. Robert Baehner. In addition, I am involved in a cancer research project with Dr. Wenxin Zheng.

    Research activities in United States:

  • 1993-June,1999:       Research Associate.       Center for Craniofacial Molecular Biology,        University of Southern California        Using the cell lines and transgenic mice models to determine amelogenin gene promoters and transcriptional factors.
  • 1990-1993:       Postdoctoral Fellowship.       Center for Craniofacial Molecular Biology,        University of Southern California        To explore amelogenin gene expression in vitro, I successfully established many ameloblast cell lines. These cell lines have been used by many research laboratories for dental and material research.

    Clinical activities in China:

    1988-1990:       Resident.       Department of OB/GYN, Peking Union Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences        Specialized at reproductive endocrine and infertility, In Vitro Fertilization and Gamete Intrafallopian Transfer.

    Research Activities in China:

    1986-1988:               Peking Union Medical College and Chinese Academy of Medical Sciences
  • Gene therapy of human beta-thalassemia.
  • Regulation of tumor cells differentiation and mechanism of erythroblasts enucleation.       Collaborated at Beijing University.

    Peer Reviewed Articles in English:

  • M. L. Paine, P. H. Krebsbach, L. S. Chen, C. T. Paine, Y. Yamada, D. Deutsch and M. L. Snead. Protein-to-protein interactions: criteria defining the assembly of the enamel organic matrix. J Dental Research, 77(3):496-502, March, 1998.
  • M. Macdougal, F. Thiemann, H. Ta, P. Hsu, L. S. Chen, M. L. Snead. Temperature sensitive SV-40 large T-Ag immortalization of murine odontoblast cell culture: establishment of clonal odontoblast cell line. Connective Tissue Research. 33: 97-103 [419-425], 1995.
  • L. S. Chen, R. Couwenhoven, W. Luo and M. L. Snead. Maintenance of amelogenin gene expression by epithelial cells of mouse enamel organ. Archives of Oral Biology. 37(1):771-778, 1992.
  • M. L. Snead, M. L. Paine, L. S. Chen, D. H. Zhou, B. Yoshida, W. Luo, Y. P. Lei, Y. H. Liu and R. E. Maxson, Jr. The murine amelogenin promoter: developmentally regulated expression in transgenic animals. Connective Tissue Res. 35:41-47, 1998.
  • J. B. Zhang, J. Yuan, and L. S. Chen. Effect of Rhodamine 123 and total Glycosides from Tripterygium Wilfordii on ultrastructures, survival and fertilizing of human sperm in vitro. Proceeding of Chinese Academy of Medical Sciences and Peking Union Medical College. 4(2):80-84, 1989. M. Dong, L. S. Chen, J.B.Zhang, S. P. Xue and Z. H. Zhai. Intermediate filament-lamina- nuclear matrix system in chicken and mouse nucleated erythroblasts. Acta Anatomica Sinica. 4:399-403,1990. L. Q. Zhu, L. S. Chen, J. Ruan and J. B. Zhang. Effect and mechanism of total glycoside from Tripterygium Wilfordii on HeLa cell. Nature J. 10:23-25, 1987. LI> M. Dong, L. S. Chen, J.B.Zhang, S. P. Xue and Z. H. Zhai. Intermediate filament-lamina- nuclear matrix system in chicken and mouse nucleated erythroblasts. Acta Anatomica Sinica. 4:399-403,1990.
  • L. S. Chen and M. L. Snead. Establishment of mouse ameloblast cell lines that retain amelogenin gene expression. Submitted.
  • M. L. Snead, M. L. Paine, L. S. Chen, D. H. Zhou, B. Yoshida, W. Luo, Y. P. Lei, Y. H. Liu and R. E. Maxson, Jr. The murine amelogenin promoter: Transient and permanent transgenic Animals. Connective Tissue Res, 1998. In press.
  • L.S. Chen and M. L. Snead. Regulation of amelogenin gene expression in mouse enamel organ epithelium cell lines.

    Invited Reviews in Chinese:

  • L.S.Chen Prospect of Somatic cell cloning. Overseas Campus Magazine, 23: 1997
  • L. S. Chen and J. B. Zhang. Organ specificity of metastasis of tumor cell. Oncology. 1:29- 32,1987.
  • L. S. Chen and J. B. Zhang. Biology and Biochemistry of fertilization. The Proceeding of Biosciences. 3:26-28, 1988.
  • L S. Chen. Tumor metastasis biology. The Proceeding of Biosceinces. 1: 29-31, 1988

    Presented Abstracts:

  • M. L. Snead, M. L. Paine, W. Luo, D. H. Zhu, Y. P. Lei, B. Yoshida, J. Burstein, L. S. Chen and C. T. Paine. Transgenic animal model for protein accumulation in forming enamel. The Sixth International Symposium on the Composition, Properties and Fundamental Structure of Tooth Enamel. Lake Arrowhead, CA. May 11-15, 1997
  • M. L. Snead, M. L. Paine, L. S. Chen, W. Luo, D. H. Zhu, Y. P. Lei, B. Yoshida, J. Burstein. The murine amelogenin promoters. (oral presentation). The 5th international conference on the chemistry and biology of mineralized tissues. Wisconsin. Oct. 1995.
  • M. L. Snead and L. S. Chen, W. Luo. Enamel organ epithelium immortalized with temperature sensitive large T-Ag. ( oral presentation). J Dental Research. 74(AADR Abstracts):94, 1995. 24th Annual meeting of American Association for Dental Research(AADR). San Antonio, TX. Mar. 1995.
  • W. Luo, L. S. Chen and M. L. Snead. Transgenic mouse model for odontogenic tumors. Molecular Biology of the Cell. 5:119a,1994. 34th Annual meeting of American Society of Cell Biology. San Francisco, CA. Dec. 1994.
  • L. S. Chen and M. L. Snead. Permanent cell lines from mouse Von Ebner gland. Molecular Biology of Cell. 5:228a, 1994. 34th Annual meeting of American Society of Cell Biology. San Francisco, CA. Dec. 1994.
  • M. MacDougal, F. Thiemann, L. S. Chen and M. L. Snead. Establishment of transformed murine odontoblast cell line. The Vth international conference on tooth morphogenesis. Kerkrad, The Netherland. 1994.
  • L. S. Chen, W. Luo and M. L. Snead. Construction and characterization of immortalized enamel organ epithelial cells. Molecular Biology of Cell. 3:202a, 1992. The 32nd Annual meeting of American Society of Cell Biology. Denver, Colorado. 1992.
  • L. S. Chen and M. L. Snead . Transformation of enamel organ epithelium by electroporation. (Oral presentation). IADR/AADR General Session. Acapulco, Mexico. April, 1991.

    Extracurricular activities:

  • 1981- present:       Writing lots of essays and poems that were published in China and America.
  • 1991-1995:        Chairman of Living Water Fellowship for Chinese Students and Scholars of USC,CalTech and UCLA.
  • 1993-present:        Participated in various activities including Mentor for Advance Precollege Science Education of California.

    Honors and Awards:

  • 1986        Magna Cum Laude.       Hunan Medical University.
  • 1985        The Campus Poet Award.       Hunan Medical University.
  • 1981-1986        Outstanding Student for Achievements and Performance annually.       Hunan Medical University
  • 1988        Outstanding Young Scientist.       Peking Union Medical College and Chinese Academy of Medical Sciences.
  • 1995        The Best Photography Award.        Asian Youth Photo Competition, Los Angeles.

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