PERSONAL INFORMATION

Business Address

University of Southern California
School of Pharmacy
1985 Zonal Avenue
Los Angeles, California 90033

Business Telephone

(323) 442-1902

FAX

(323) 442-1390

e-mail

weishen@hsc.usc.edu

 

EDUCATION

1965

- Tunghai University, Chemistry Department, Taichung, Taiwan (Bachelor of Science)

1972

- Boston University, Chemistry Department, Boston, Massachusetts (Ph.D., Major in Bio-organic Chemistry)

 

PROFESSIONAL EXPERIENCE

1992-present

- Professor of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles

1987-92

- Associate Professor of Pharmacy, School of Pharmacy, University of Southern California, Los Angeles

1983-87

- Associate Professor of Pathology and Pharmacology, School of Medicine, Boston University, Boston

1980-83

- Associate Research Professor of Pathology and Pharmacology, School of Medicine, Boston University, Boston

1976-80

- Assistant Research Professor of Pathology and Pharmacology, School of Medicine, Boston University, Boston

1973-76

- Senior Research Associate, Biochemistry Department, Brandeis University, Waltham, Massachusetts

1972-73

- Research Fellow, Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts

 

OTHER PROFESSIONAL EXPERIENCE

1993-present

- Vice Chairman, Department of Pharmaceutical Sciences, University of Southern California School of Pharmacy

1989-1992

- Director of Graduate Affairs, University of Southern California School of Pharmacy

1986

- Visiting Professor, Department of Pathology, North China Coal Medical College, Hebei, China

1984-86

- Administrator of the Upjohn Graduate Fellowship in Pharmaceutical Chemistry

1979-86

- Visiting Lecturer in Biochemical Toxicology, Department of Biochemistry, Brandeis University

1983-84

- Principal, Newton Chinese Language School, Newton, Massachusetts

 

GRANT REVIEWER

National Institutes of Health

National Science Foundation

Medical Research Council of Canada

North Carolina Biotechnology Center

 

EDITORIAL BOARD

1995-

- Editorial Advisory Board, Pharmaceutical Research

1993-

- Editorial Board, Journal of Drug Targeting

 

JOURNAL REFEREE

Analytical Biochemistry, Archieves of Biochemistry and Biophysics, Biochemical Pharmacology, Biochimica et Biophysica Acta,, Cancer Research, CRC Critical Review, European Journal of Pharmaceutics and Biopharmaceutics, Immunology Letters, International Journal of Pharmaceutics, International Journal of Cancer, Journal of Cellular Physiology, Journal of Controlled Release, Journal of Drug Targeting, Journal of Medicinal Chemistry, Journal of Pharmaceutical Sciences, Pharmaceutical Research.

 

EXTERNAL DOCTORAL THESIS EXAMINER

1986

Dalhousie University, Halifax, Nova Scotia, Canada

1994

University of the Witwatersrand, Johannesburg, South Africa

 

PROFESSIONAL SOCIETIES

Fellow, American Association of Pharmaceutical Scientists

Member, American Society for Biochemistry and Molecular Biology

Member, American Society for Pharmacology and Experimental Therapeutics

Member, Controlled Release Society

Member, American Association of Advancement of Science

 

Current Research Interest

1.

Endocytosis and lysosomal degradation of macromolecules in mammalian cells.

2.

Transcytosis of macromolecules in epithelial cells.

3.

Growth inhibitory proteins and angiogenesis.

4.

Cancer chemopreventive agents.

5.

Lipidization of peptides and oligonucleotides

 

INVENTIONS AND PATENTS

US Patent No. 4,631,190: "Acidity-Sensitive Spacer Molecule to Control the Release of Pharmaceuticals from Molecular Carriers."

US Patent No. 4,847,240: "Method of Effecting Cellular Uptake of Molecules."

US Patent No. 5,254,342: "Compositions and Methods for Enhanced Transepithelial and Transendothelial Transport of Active Agents."

US Patent pending: "Methods and Compositions for Lipidization of Hydrophilic Molecules."

US Patent pending: "Reversible Lipidization of Disulfide Cyclopeptides."

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